Curcumin suppresses intestinal microvascular endothelial cells invasion and angiogenesis induced by activated platelets
Identifieur interne : 000920 ( Main/Exploration ); précédent : 000919; suivant : 000921Curcumin suppresses intestinal microvascular endothelial cells invasion and angiogenesis induced by activated platelets
Auteurs : Su Xu [République populaire de Chine] ; Zhao-Xiu Xu [République populaire de Chine] ; Shuai Yan [République populaire de Chine] ; Jin Le [République populaire de Chine] ; Hao Chen [République populaire de Chine] ; Lan Ming [République populaire de Chine] ; Shu-Guang Xu [République populaire de Chine] ; Tao Lin [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2019.
Abstract
The present study investigated the effects and mechanism by which curcumin suppresses intestinal microvascular endothelial cells (INMECs) invasion and angiogenesis induced by activated platelets. INMECs were obtained from healthy rats, and divided into five groups: Control, platelets, platelets +2.5 µM curcumin, platelets +5.0 µM curcumin and platelets +10.0 µM curcumin. Curcumin toxicity was determined and vascular endothelial growth factor (VEGF) concentrations of the five groups were measured using ELISA. The branch point numbers were measured using a capillary tube formation experiment, invasion cell numbers were evaluated with the Transwell assay, relative protein expression levels were measured with western blot assay and immunofluorescence staining of the nucleus. The 2.5, 5 and 10 µM curcumin concentrations were found to be suitable for INMECs. Curcumin significantly downregulated VEGF concentration, suppressed vascular lumen formation and inhibited invasion cell numbers in a dose-dependent manner. The α-smooth muscle actin, collagen I, E-cadherin, phosphorylated (p-) phosphoinositide 3-kinase (PI3K), p-protein kinase B (AKT), p-mammalian target of rapamycin (m-TOR) and hypoxia inducible factor subunit alpha (HIF-1α) protein expression levels of the curcumin-treated groups were significantly downregulated in a dose-dependent manner compared with the platelet group. HIF-1α protein expression levels in the nucleus of the curcumin-treated groups were significantly suppressed in a dose-dependent manner compared with the platelet group. In conclusion, curcumin suppressed INMEC invasion and angiogenesis induced by activated platelets via inhibiting the activation of the PI3K/AKT/mTOR pathway.
Url:
DOI: 10.3892/etm.2019.7662
PubMed: 31316605
PubMed Central: 6601414
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Zhao Xiu" sort="Xu, Zhao Xiu" uniqKey="Xu Z" first="Zhao-Xiu" last="Xu">Zhao-Xiu Xu</name><affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-7662">Department of Colorectal Surgery, Kongjiang Hospital of Yangpu, Shanghai 200433, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Shu Guang" sort="Xu, Shu Guang" uniqKey="Xu S" first="Shu-Guang" last="Xu">Shu-Guang Xu</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Tao" sort="Lin, Tao" uniqKey="Lin T" first="Tao" last="Lin">Tao Lin</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31316605</idno><idno type="pmc">6601414</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601414</idno><idno type="RBID">PMC:6601414</idno><idno type="doi">10.3892/etm.2019.7662</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000515</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000515</idno><idno type="wicri:Area/Pmc/Curation">000515</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000515</idno><idno type="wicri:Area/Pmc/Checkpoint">000859</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000859</idno><idno type="wicri:Area/Ncbi/Merge">000813</idno><idno type="wicri:Area/Ncbi/Curation">000813</idno><idno type="wicri:Area/Ncbi/Checkpoint">000813</idno><idno type="wicri:doubleKey">1792-0981:2019:Xu S:curcumin:suppresses:intestinal</idno><idno type="wicri:Area/Main/Merge">000920</idno><idno type="wicri:Area/Main/Curation">000920</idno><idno type="wicri:Area/Main/Exploration">000920</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Curcumin suppresses intestinal microvascular endothelial cells invasion and angiogenesis induced by activated platelets</title><author><name sortKey="Xu, Su" sort="Xu, Su" uniqKey="Xu S" first="Su" last="Xu">Su Xu</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Zhao Xiu" sort="Xu, Zhao Xiu" uniqKey="Xu Z" first="Zhao-Xiu" last="Xu">Zhao-Xiu Xu</name><affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-7662">Department of Colorectal Surgery, Kongjiang Hospital of Yangpu, Shanghai 200433, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Colorectal Surgery, Kongjiang Hospital of Yangpu, Shanghai 200433</wicri:regionArea><wicri:noRegion>Shanghai 200433</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Shuai" sort="Yan, Shuai" uniqKey="Yan S" first="Shuai" last="Yan">Shuai Yan</name><affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-7662">Department of Anorectal Surgery, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu 215009, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu 215009</wicri:regionArea><wicri:noRegion>Jiangsu 215009</wicri:noRegion></affiliation></author><author><name sortKey="Le, Jin" sort="Le, Jin" uniqKey="Le J" first="Jin" last="Le">Jin Le</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name><affiliation wicri:level="1"><nlm:aff id="af4-etm-0-0-7662">Department of Anorectal Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009</wicri:regionArea><wicri:noRegion>Jiangsu 210009</wicri:noRegion></affiliation></author><author><name sortKey="Ming, Lan" sort="Ming, Lan" uniqKey="Ming L" first="Lan" last="Ming">Lan Ming</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Shu Guang" sort="Xu, Shu Guang" uniqKey="Xu S" first="Shu-Guang" last="Xu">Shu-Guang Xu</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Tao" sort="Lin, Tao" uniqKey="Lin T" first="Tao" last="Lin">Tao Lin</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7662">Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anorectal Surgery, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224001</wicri:regionArea><wicri:noRegion>Jiangsu 224001</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental and Therapeutic Medicine</title><idno type="ISSN">1792-0981</idno><idno type="eISSN">1792-1015</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The present study investigated the effects and mechanism by which curcumin suppresses intestinal microvascular endothelial cells (INMECs) invasion and angiogenesis induced by activated platelets. INMECs were obtained from healthy rats, and divided into five groups: Control, platelets, platelets +2.5 µM curcumin, platelets +5.0 µM curcumin and platelets +10.0 µM curcumin. Curcumin toxicity was determined and vascular endothelial growth factor (VEGF) concentrations of the five groups were measured using ELISA. The branch point numbers were measured using a capillary tube formation experiment, invasion cell numbers were evaluated with the Transwell assay, relative protein expression levels were measured with western blot assay and immunofluorescence staining of the nucleus. The 2.5, 5 and 10 µM curcumin concentrations were found to be suitable for INMECs. Curcumin significantly downregulated VEGF concentration, suppressed vascular lumen formation and inhibited invasion cell numbers in a dose-dependent manner. The α-smooth muscle actin, collagen I, E-cadherin, phosphorylated (p-) phosphoinositide 3-kinase (PI3K), p-protein kinase B (AKT), p-mammalian target of rapamycin (m-TOR) and hypoxia inducible factor subunit alpha (HIF-1α) protein expression levels of the curcumin-treated groups were significantly downregulated in a dose-dependent manner compared with the platelet group. HIF-1α protein expression levels in the nucleus of the curcumin-treated groups were significantly suppressed in a dose-dependent manner compared with the platelet group. In conclusion, curcumin suppressed INMEC invasion and angiogenesis induced by activated platelets via inhibiting the activation of the PI3K/AKT/mTOR pathway.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Baumgart, Dc" uniqKey="Baumgart D">DC Baumgart</name></author><author><name sortKey="Sandborn, Wj" uniqKey="Sandborn W">WJ Sandborn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Zj" uniqKey="Liu Z">ZJ Liu</name></author><author><name sortKey="Yadav, Pk" uniqKey="Yadav P">PK Yadav</name></author><author><name sortKey="Su, Jl" uniqKey="Su J">JL Su</name></author><author><name sortKey="Wang, Js" uniqKey="Wang J">JS Wang</name></author><author><name sortKey="Fei, K" uniqKey="Fei K">K Fei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramsewak, Rs" uniqKey="Ramsewak R">RS Ramsewak</name></author><author><name sortKey="Dewitt, Dl" uniqKey="Dewitt D">DL 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Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Su" sort="Xu, Su" uniqKey="Xu S" first="Su" last="Xu">Su Xu</name></noRegion><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name><name sortKey="Le, Jin" sort="Le, Jin" uniqKey="Le J" first="Jin" last="Le">Jin Le</name><name sortKey="Lin, Tao" sort="Lin, Tao" uniqKey="Lin T" first="Tao" last="Lin">Tao Lin</name><name sortKey="Ming, Lan" sort="Ming, Lan" uniqKey="Ming L" first="Lan" last="Ming">Lan Ming</name><name sortKey="Xu, Shu Guang" sort="Xu, Shu Guang" uniqKey="Xu S" first="Shu-Guang" last="Xu">Shu-Guang Xu</name><name sortKey="Xu, Zhao Xiu" sort="Xu, Zhao Xiu" uniqKey="Xu Z" first="Zhao-Xiu" last="Xu">Zhao-Xiu Xu</name><name sortKey="Yan, Shuai" sort="Yan, Shuai" uniqKey="Yan S" first="Shuai" last="Yan">Shuai Yan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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